Description:

Noziheptide 1%-TRV is an antimicrobial veterinary product.

Dosage form: oral powder in package 20 kg

Composition

1 gram of the product contains 10 mg of nosiheptide, excipients (trilon B, silicon dioxide) and excipient (sucrose).

Indications for use:

The veterinary product is used for treatment of young cattle, pigs, rabbits and poultry against clostridiosis, eschirichiosis, salmonellosis, staphylococcosis, streptococcosis and other infectious bacterial diseases caused by microorganisms sensitive to nosiheptide.

Method of administration and dosage:

The preparation is administered as a group dose in mixture with feed for 14 days.

Young poultry

250 gram/1 t of feed.

Laying hens

200-250 gram/1 t of feed.

Suckling piglets, growing pigs, fattening pigs, breeding sows and boars

300-500 gram/t feed.

Gestating, lactating sows

800-1000 gram / 1 ton of feed.

Calves (up to 3 months of age)

300-500 gram/1 t feed.

Rabbits

500-1000 gram/1 t feed.

Pharmaceutical properties

The active ingredient of the veterinary product is nosiheptide, a bicyclic thiopeptide produced by the fungus Streptomyces actuosus. Nosiheptide has a marked antibacterial effect on Gram-positive bacteria and some Gram-negative bacteria, including all types of Clostridium spp., Escherichia coli, Staphylococcus aureus, Streptococcus pyogenes haemolyticus, Streptococcus viridans, Streptococcus faecalis, Diplococcus pneumoniae, Salmonella spp. and other. Does not have an adverse effect on obligate micro-organisms in the gastrointestinal tract.

The mechanism of antibacterial action of the veterinary product is to disrupt bacterial protein synthesis; it inhibits the function of elongation factors Tu and G and significantly reduces guanosine penta- and tetraphosphate synthesis in response to the stringent factor. This involves specific pentose methylation of the 23-s ribosome. Nosiheptide acts on the 50-s ribosomal subunits and binds the 23-s p-RNA complex to the L11 ribosomal protein.

When administered orally, nosiheptide is not absorbed from the gastrointestinal tract and forms a high concentration in the lumen. Nosiheptide does not accumulate in tissues and is excreted from the body unchanged.

The veterinary product is low-toxic, in the recommended doses has no mutagenic, sensitizing, embryotoxic and teratogenic effect, has no adverse effect on the quality of meat products.